Superiority
Molecular formula
C5H4ClNO2
CAS No.
103766-25-2
Identification
White or almost white crystalline powder
Use and Background
TS-1 is an an…
Details
Molecular formula
C5H4ClNO2
CAS No.
103766-25-2
Identification
White or almost white crystalline powder
Use and Background
TS-1 is an anticancer drug containing three components, tegafur, an oral anticancer drug which is a prodrug of 5-fluorouracil (5-FU), 5-chloro-2,4-dihydroxypyridine (CDHP) and monopotassium 1,2,3,4-tetrahydro-2,4-dioxo-1,3,5-triazine-6-carboxylate (Oxo) . CDHP inhibits the decomposition of 5-FU, whereby it maintains a high concentration of 5-FU in blood. Oxo inhibits the phosphorylation of 5-FU, whereby it attenuates the toxic effects of 5-FU on the gastrointestinal tract.